Fig. 7
From: SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
CDC25A(△E6) production is indispensable for SRSF10-mediated HCC progression in vitro and in vivo. A, B, C The validation of endogenous CDC25A(L), CDC25A(△E6), or all CDC25A(FL) knockdown by semi-RT‒PCR using three primer sets. D, E, F, G Effects of SRSF10 and diverse CDC25A variants on the cell viability (D), proliferation (E), invasion (F), and cell cycle (G) of HCC. Functional recovery experiments were conducted under silencing of CDC25A(L), CDC25A(△E6), and all endogenous CDC25A(FL) under circumstances of SRSF10 overexpression. Data are presented as the mean ± SD value of three biological replicates. ***p < 0.001 vs. sh-CDC25A(L), t test. See representative images in Supplementary Fig. 11