Fig. 6
From: SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
MYCN-associated GSEA signatures in SMAD9-high NB cells and tumors. A, B Representative GSEA of MYCN-associated gene sets in the SMAD9-high and SMAD9-low groups among BE(2)-C (A) and IMR-32 cells (B) with FDR and NOM p values. C Lollipop chart showing the correlation value between SMAD9 and MYCN (or MYCNOS or MYC family members) in different datasets and the SCH cohort. D Representative GSEA of MYCN-associated gene sets in the SMAD9-high and SMAD9-low groups in different high-risk NB cohorts. EGAS: dataset EGAS00001001308; GSEA: gene set enrichment analysis; shSCR: shRNA scrambled control; SCH: Shanghai Children Hospital; TARGET: therapeutically applicable research to generate effective treatments