Fig. 2

SLC7A11 expression is correlated with sorafenib resistance in HCC cells. A Expression of ferroptosis-related genes detected in parental cells and SR cells. B and C SLC7A11 expression level in parental and SR cells as determined by western blot analysis. D and E SLC7A11 expression levels in parental and SR cells as determined by IF analysis. F Volcano plot showing differentially expressed genes between the parental and resistant cells in the GSE158458 gene set, where SLC7A11 is highly expressed in both sorafenib resistant Huh7 and Hep3B cells. *p < 0.05; **p < 0.01; ***p < 0.001