Fig. 1

Correlation between ENO2 expression level and HNSCC development. a Analysis of ENO2 expression in normal and tumor tissues using TCGA cohort with 33 cancer types. b The expression levels of ENO2 in head and neck normal and tumor tissues using GEO dataset. c Kaplan-Meier survival analysis of the correlation between the expression levels of ENO2 and survival in HNSCC patients. d Chi-square test analysis of the correlation between the expression levels of ENO2 and clinical stage of HNSCC patients. e, f ENO2 expression levels in human primary HNSCC samples (n=52) and normal tissues (n=19) determined by IHC. Representative IHC result and quantitative data are shown in e and f, respectively. g, h Transcriptional (g) and protein levels (h) of ENO2 in different HNSCC cell lines determined by qRT-PCR and western blotting, respectively. **p<0.01