Fig. 7

Schematic illustration of RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in Triple Negative Breast Cancer (by Figdraw). RNF31 could associate with YAP protein and promote YAP protein K48-linked poly-ubiquitination and degradation, which subsequently inhibited YAP-driven signaling function and TNBC progression. Besides, RNF31 could also prevent tumor immune evasion via inhibiting Hippo/YAP/PD-L1 axis