Fig. 4

METTL3 affects the Hippo pathway and glycolysis in breast cancer cells. a Knocking out METTL3 remarkably affected transcriptome expression in MCF-7 cells. b KEGG enrichment analysis indicated that the Hippo pathway was upregulated, whereas glycolysis progression was downregulated by MTEEL3 knockout. c RNA-seq results showed that multiple differentially expressed genes involved in different pathways were significantly related to METTL3, n = 3. d KEGG enrichment of differential metabolites from metabolomic-seq analysis demonstrated that metabolites of glycolysis progression could be largely affected by METTL3, n = 6