Fig. 7

Rescuing the protein level of LATS1 by altering the expression of YTHDF2 in breast cancer cells could help suppress tumorigenesis. a YTHDF2 deletion remarkably suppressed glycolysis progression in MCF-7 cells, *** p < 0.001. b Knocking out the expression of YTHDF2 significantly inhibited tumor growth in vivo, n = 7, * p < 0.05, ** p < 0.01. c The colony formation ability of MCF-7 cells was suppressed by knocking out the expression of YTHDF2 and reversed by inhibiting the expression of LATS1 at the same time. d YTHDF2 overexpression led to the rapid proliferation of MCF-7 cells and such stimulation could be rescued by LATS1 knockdown, n = 3, ** p < 0.01. e YTHDF2 deletion raised the apoptosis level of MCF-7 cells, while LATS1 knockdown rescued this stimulation, n = 3, ** p < 0.01, *** p < 0.001. f The suppressed invasion ability of MCF-7 cells affected by YTHDF2 knockout could be rescued by LATS1 knockdown, n = 3, ** p < 0.01, *** p < 0.001