Table 3 Upregulations of immune checkpoints in D374Y tumors
From: PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity
Human Gene | Gene ID | Mouse gene | Gene ID | log2(FC) | StdErr | P.values | P.adj |
|---|---|---|---|---|---|---|---|
CD244 | 51,744 | Cd244a | 18,106 | 2.500953 | 0.521179 | 1.60E-06 | 3.40E-05 |
CD274 | 29,126 | Cd274 | 60,533 | 2.018645 | 0.350979 | 8.85E-09 | 2.61E-07 |
CD96 | 10,225 | Cd96 | 84,544 | 3.421428 | 0.496495 | 5.53E-12 | 2.27E-10 |
CSF1R | 1436 | Csf1r | 12,978 | 2.680561 | 0.335431 | 1.33E-15 | 7.68E-14 |
CTLA4 | 1493 | Ctla4 | 12,477 | 2.340851 | 0.598397 | 9.16E-05 | 0.001376 |
IL10 | 3586 | Il10 | 16,153 | 2.504071 | 0.596343 | 2.68E-05 | 0.00046 |
LAG3 | 3902 | Lag3 | 16,768 | 3.234851 | 0.311465 | 2.87E-25 | 3.35E-23 |
PDCD1 | 5133 | Pdcd1 | 18,566 | 4.632033 | 0.534352 | 4.38E-18 | 3.21E-16 |
PDCD1LG2 | 80,380 | Pdcd1lg2 | 58,205 | 2.624019 | 0.398335 | 4.47E-11 | 1.70E-09 |
TGFB1 | 7040 | Tgfb1 | 21,803 | 1.265117 | 0.310199 | 4.53E-05 | 0.000732 |
TIGIT | 201,633 | Tigit | 1E + 08 | 3.786159 | 0.51301 | 1.58E-13 | 7.83E-12 |