Fig. 3

Event-free survival (EFS) at 5 years in ALL patients from the discovery cohort according to (A) maximum total bilirubin toxicity grade during induction/consolidation (protocols IA/IB); (B) rs6744284 genotype (CC, TC, TT); and (C) homozygosity for the UGT1A1*28 or *37 allele. D illustrates the EFS by rs6744284 genotype (CC/TC and TT) restricted to patients with high bilirubinemia (n = 68; grades 3 and 4). Bilirubin toxicity grading was according to the Common Toxicity Criteria (CTC) of the National Cancer Institute, version 2; standard error (SE) and the number of included individuals are indicated for each category