Fig. 6
Proteotranscriptomic characterization of Palbociclib responder line in comparison with no-responder ones. (A) Network mapping of 111 proteins showing the 4 clusters composed of more than 3 proteins. Proteins with no associations to others were removed and nodes are colored according to the protein abundance (log2ratio) compared to responder PDO (left panel). Bar-chart of GO terms represented as percentage of annotated proteins using the same color coding (right panel). (B) Hierarchical clustering heatmap of differentially expressed genes per transcriptomic. (C) GSEA hallmarks analysis of RNA-seq data. NES: normalized enrichment score. FDR: false discovery rate. R: responder; NR: non responder