Fig. 2

rs104886038 and DHCR7 play important roles in GC. A Manhattan plot for the GWAS based on the analysis of the training set with the additive model. B Significant SNPs confirmed in the validation set. C ROC of the SNP model for GC diagnosis. D Forest plots for risk factors for GC. OR(95%CI) and P value of OR were calculated based on the logistic regression model. E In the TCGA and GSE66229 datasets, DHCR7 was upregulated in GC tissues compared with normal tissues (***FDR < 0.001). F The results of functional enrichment analysis of genes coexpressed with DHCR7. G The expression of DHCR7 in GC tissues with different pathological TNM stages, primary tumor invasion depths, lymph node metastasis statuses, distant metastasis statuses and differentiation grades (calculated by Student’s t test, *P < 0.05; **P < 0.01; ***P < 0.001)