Fig. 9From: Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recyclingA Schematic diagram of the treatment of an OSCC PDX model. Three cycles of intravenous injection of NPs and 6 observations were applied when the tumor volume was approximately 60 mm3. B Photographs of collected xenografts on Day 20. Among the groups, the NPs-siLCN2 group displayed the smallest xenografts. C Tumor proliferation in each group. The inhibition of tumor growth was significant in the NPs-siLCN2 group compared to that in the other groups. D Comparison of tumor weight on the last day (Day 20). E Histological detection of HE, LCN2, p-EGFR and Ki67 in the tumor tissues; the results suggested that when LCN2 was inhibited, p-EGFR and Ki67 expression was reduced. (Scale bar: 50 μm). F Immunoblot detection of tumor homogenates. The results showed that LCN2 expression was downregulated in tumors from the nano-siLCN2 groupBack to article page