Fig. 1

IGF1R was overexpressed in OSCC and associated with disease progression and poor prognosis. A Expression of common RTKs in OSCC tissues compared to adjacent normal tissues from RNA-seq data gathered from the TCGA. B A subset of abnormally expressed genes concerning RTKs in OSCC tissues (left) or in KYSE150 cells under limited-oxygen conditions (right) from RNA-seq data based on our specimens. C Venn diagram for crossovers of two subsets of genes in Fig. 1B. D, E Expression of IGF1R at protein levels in OSCC cell lines under different oxygen concentrations (D) and different times duration of hypoxia (E). F Representative TMA images of IGF1R protein in different OSCC stage specimens (Ib–IV) or adjacent normal tissue specimens. Scale bars represent 100 mm. G IHC scores of IGF1R in OSCC or normal tissues (left), Student’s t test; Percentage of high scores in 0–IV stage OSCC (right), Chi-squared test. H Correlation between the overall survival of OSCC patients and IGF1R expression. I Expression of IGF1R in OSCC tissues compared to adjacent normal tissues from representative clinical patients (n = 5). J Representative IHC images of IGF1R protein in EOC tissues or adjacent normal tissues. Scale bars represent 100 mm. K IHC scores of IGF1R in EOC tissues compared to normal tissues. NS: not signifcant, *p < 0.05, **p < 0.01, ***p < 0.001