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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

Fig. 7

Blockade of the FBXW7/MAP4/ERK axis suppresses esophageal squamous cell carcinoma cell growth. A Short-term cell viability assay measuring the IC50s of MK-8353 in different ESCC cell lines. B The survival rate of FBXW7 wild-type cells, FBXW7-KO cells (gFBXW7-1) or FBXW7-KO cells transfected with FBXW7-S327X which were treated with different concentration of MK-8353. C Representative images of tumors from the indicated groups. D The weights of tumors from the indicated groups. E Tumor growth curve of tumors from the indicated groups. F Immunohistochemical photos of PCNA expression in tumor samples from the indicated groups. Means ± SEM are shown. *, p < 0.05, **, p < 0.01, ***, p < 0.001

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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