Fig. 7
From: TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
In vitro down-regulation of DNA repair gene signature. A WB analysis of DNA ligase I, PARP1 and RAD51 after 48 h of hit 17 treatments in the NCI-H929, AMO-1, and RPMI-8226 cell lines. B-D Gene expression levels of LIG1, PARP1 and RAD51 in MM samples compared to HD. E–G The survival analysis of 414 MM patients from GSE4581 classified according to gene expression levels: high (red) or low (blue). We used as a scale to plot OS the days’s scale. FC: fold change; P: p-value; HR: Hazard Ratio; n: number of patients. ****P < 0.0001