Fig. 3
From: Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
The mechanism of tumor-serected exosomal cargos regulate metabolic reprogramming of CAFs. TEXs can be delivered to NFs and stellate cells. Breast cancer cells-secreted exosomal miR-105 can target MXI1 to activate the MYC pathway and enhance the glycolysis, glutamine breakdown, lactate secretion and NH4 + clearance of CAFs. HCC cells-secreted exosomal HSPC111 can promote ACLY expression to alter lipid metabolism of CAFs. TNBC cells-secreted exosomal ITGB4 can induce BNIP3L-dependent lactate production in CAFs. CRC-derived exosomes can promote GAA of CAFs and up-regulate SHMT2, IDH2, GLUT-1, MCT4 and SLC1A5/3A5 expression