Fig. 3
From: METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
Effect of METTL3 on SCLC chemoresistance in vivo. A Tumour growth in the METTL3 knockdown groups was measured. H69AR cells were stably transduced with shNC or shMETTL3. Cells were subcutaneously injected into nude mice, and chemotherapeutic drugs or vehicles were administered intraperitoneally. ***P < 0.001. B-C Effect of METTL3 on resistance to chemotherapeutic drugs in nude mice and measurement of the tumour weights ***P < 0.001. D Representative IHC staining of METTL3 in subcutaneous xenografts with or without METTL3 knockdown. Scale bars, 50 μm. E Tumour growth in the METTL3 overexpression groups was measured. H69 cells stably overexpressing METTL3 or control cells were subcutaneously injected into nude mice, and chemotherapeutic drugs or vehicles were administered intraperitoneally. ***P < 0.001. F-G Effect of METTL3 on sensitivity to chemotherapeutic drugs in nude mice and measurement of the tumour weights of different groups. ***P < 0.001. H Representative IHC staining of METTL3 in subcutaneous xenografts with or without METTL3 overexpression. Scale bars, 50 μm