Fig. 4
Gene expression profiles and genomic mutations landscape in PDOs. A Representative images of the PDOs established from patients PCRC-1–3, their mutations in known CRC-related genes, and TNM stage, CMS, CRIS and MSS/MSI classification. Scale bars represent 200 μm, B. Gene expression changes of established PDOs from PCRC1-3 after treatment with ODCLSFXR for 72 h (N = 3). Differentially expressed pathways (Genes with the |log2FC|> 2) are highlighted in the right panel