Table 3 Single-sample GSVA analysis on EGFR-containing gene sets
Gene Set | EGFR subgroupsa | Mean GSVA score | P-valueb | ||
|---|---|---|---|---|---|
(nomenclature reported in Fig. 3A) | A | Bc | A | B | |
GOBP_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY (EGFR_signaling_pathway) (113) {123]d | 0 | M | -0,0288 | -0,0162 | 0,588 |
0 | MM | -0,0288 | 0,1576 | 0,007 | |
M | MM | -0,0162 | 0,1576 | 0,009 | |
GOBP_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY (Negative_regulation_of_ERBB) (47) [53] | 0 | M | -0.0049 | 0.0042 | 0.783 |
0 | MM | -0.0049 | 0.1789 | 0.024 | |
M | MM | 0.0042 | 0.1789 | 0.028 | |
GOBP_REGULATION_OF_ERBB_SIGNALING_PATHWAY (Regulation_of_ERBB) (87) [96] | 0 | M | -0,0195 | -0,0151 | 0,857 |
0 | MM | -0,0195 | 0,1605 | 0,0003 | |
M | MM | -0,0151 | 0,1605 | 0,0002 | |
GOBP_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR (EGF_response) (44) [46] | 0 | M | 0,0001 | -0,0067 | 0,84 |
0 | MM | 0,0001 | 0,1768 | 0,038 | |
M | MM | -0,0067 | 0,1768 | 0,033 | |
GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY (TRPK_activity) (79) [80] | 0 | M | -0,059 | -0,0287 | 0,178 |
0 | MM | -0,059 | 0,1569 | 0,018 | |
M | MM | -0,0287 | 0,1569 | 0,03 | |
GOMF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY (TRPTK_activity) (60) [61] | 0 | M | -0,0667 | -0,0456 | 0,348 |
0 | MM | -0,0667 | 0,1309 | 0,032 | |
M | MM | -0,0456 | 0,1309 | 0,046 | |