Table 4 Upstream regulators, included in the EGFR-related gene sets, predicted by IPA. The complete lists of their target genes are reported in Sup Table 6

EGF_Response^a

 AGT

growth factor

2,535

1.97E-03

 ERK

group

2,378

5.11E-07

 TNF

cytokine

2,298

3.45E-04

 OSM

cytokine

2,236

7.57E-04

 AR

ligand-dependent nuclear receptor

2,222

6.52E-05

 IGF1

growth factor

2,199

1.54E-08

 IL4

cytokine

2,177

2.48E-03

 nicotine

chemical drug

2,136

8.64E-05

 TP63

transcription regulator

2,122

1.68E-09

 EGFR

kinase

2,122

4.51E-07

 HDAC2

transcription regulator

2,000

2.72E-04

EGFR_Singnaling_Pathway^a

 Insulin

group

3,415

4.69E-05

 8-bromo-cAMP

chemical reagent

2,547

2.87E-04

 GNA12

enzyme

2,414

1.33E-07

 medroxyprogesterone acetate

chemical drug

2,361

3.41E-02

 AGT

growth factor

2,201

1.45E-07

 TCF7L2

transcription regulator

2,200

1.61E-02

 NFE2L2

transcription regulator

2,179

8.76E-02

 MYC

transcription regulator

2,095

5.07E-02

 estrogen

chemical drug

2,025

1.59E-05

 PTP4A1

phosphatase

2,000

2.95E-03

TRPK^a

 FSH

complex

3,102

1.47E-08

 MYC

transcription regulator

2,689

2.54E-05

 FGF2

growth factor

2,639

1.99E-10

 PDGF BB

complex

2,560

2.03E-04

 8-bromo-cAMP

chemical reagent

2,534

2.76E-08

 tretinoin

chemical—endogenous mammalian

2,495

1.66E-09

 EGF

growth factor

2,370

3.32E-07

 EPAS1

transcription regulator

2,364

2.83E-05

 KLF4

transcription regulator

2,271

1.40E-09

 sphingosine-1-phosphate

chemical—endogenous mammalian

2,236

1.69E-04

 NANOG

transcription regulator

2,219

2.49E-05

 topotecan

chemical drug

2,219

5.05E-04

 bleomycin

biologic drug

2,219

8.12E-04

 Z-LLL-CHO

chemical—protease inhibitor

2,219

8.13E-03

 HGF

growth factor

2,211

7.79E-03

 ESR1

ligand-dependent nuclear receptor

2,027

1.80E-09

 TNF

cytokine

2,010

7.88E-09