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Table 5 Networks generated by IPA for the EGFR-related gene sets. The list of gene included in each network is reported in Sup. Table 7

From: Biological and clinical impact of membrane EGFR expression in a subgroup of OC patients from the phase IV ovarian cancer MITO-16A/MANGO-OV2A trial

Networks

Score

Focus Molecules

Top Diseases and Functions

EGF_Responsea

 1

31

16

Cellular Movement, Connective Tissue Development and Function, Cellular Development

 2

31

16

Hair and Skin Development and Function, Organ Development, Protein Degradation

 3

28

15

Cellular Assembly and Organization, Cellular Function and Maintenance, Infectious Diseases

 4

21

12

Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease

 5

19

11

Cellular Movement, Nervous System Development and Function, Cellular Development

EGFR_Signaling_Pathwaya

 1

24

11

Cell Death and Survival, Cell Morphology, Cellular Development

 2

21

10

Cellular Development, Embryonic Development, Organismal Development

 3

16

8

Cancer, Developmental Disorder, Embryonic Development

 4

9

5

Infectious Diseases, Hematological Disease, Cardiovascular Disease

 5

9

5

Connective Tissue Disorders, Dermatological Diseases and Conditions, Developmental Disorder

TRPKa

 1

42

19

Post-Translational Modification, Cancer, Organismal Injury and Abnormalities

 2

31

15

Cancer, Organismal Injury and Abnormalities, Respiratory Disease

 3

28

14

Post-Translational Modification, Cell Signaling, Developmental Disorder

 4

23

12

Cancer, Endocrine System Disorders, Gastrointestinal Disease

 5

16

9

Cell Morphology, Embryonic Development, Hair and Skin Development and Function

  1. aThe detailed nomenclature of the EGFR-related geene sets is reported in Table 3