Fig. 2

PDOs retained histological and genomic features of the original tumor. a Histological comparison of representative HGSOC PDOs and their parental tumor tissue. The panel shows hematoxylin eosin (H&E) staining, cytokeratin 7 (CK7), CK20, PAX8 and p53 immunostaining in HGSOC tumor tissue (magnification 20 ×) and corresponding PDOs (magnification 40 ×). Scale bar, 100 μm. b Somatic mutations and amplifications/deletions in relevant genes of ovarian cancer. For each sample, tumor/organoid pairs are displayed and indicated by color coding (pink, tumors; orange, organoids)