Fig. 1

The upregulated expression of PKM2 in CRC and CRLM. (A) Primary CRC patients overexpressed pkm2 mRNA compared to normal tissue in the TCGA database. (B) Patients with low pkm2 expression in the TCGA database had significantly longer DSS (p = 0.01) than those with high pkm2 expression. (C) In the GSE21510 data set, the expression of pkm2 mRNA of liver tissue of normal, CRC, and CRLM. (D) and (E) The expression and grayscale analysis of PKM2 in various colorectal cancer cells. (F) Immunohistochemistry of PKM2 of liver tissue in normal or CRLM mice. CRC: Colorectal cancer cells; CRLM: Colorectal cancer liver metastasis. Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001