Fig. 3
The HBV-related immune alteration in INT and TB tissues. A The number of samples in patient groups used for identification of HBV-related immune alterations. B The PCA projections of immune signatures for all samples, colored by different sample groups. C and D Frequency comparisons of the meta-clusters between HBV+ and HBV− patients in INT tissues (C) and TB tissues (D). E The correlation plots between the frequency of C15 and ALT (left), and the frequency of C16 (right) in TB tissues of HBV+ patients. F The heatmap shows the significant level of frequency comparison for meta-cluster across TB tissues of HBV+ patients grouped by different histopathological scores, colored by the signed -log10(p-value). G Frequency comparisons of the meta-cluster in TB tissues of HBV+ patients grouped by different histopathological scores. HBV infected HCC patients were divided into low-grade or high-grade liver disease based on criteria using Fibrosis Score and/or Necroinflammatory Activity Score as listed in supplemental table 7. Unpaired student’s t-test was used in (C, D, F, and G), with *p < 0.05, **p < 0.01, and ***p < 0.001. Spearman correlation was used in E, the correlation coefficients and p-value was labeled