Fig. 5

Transcriptomics profiling of PD-1⁺CD8⁺ T_RM cells across HBV infection and tissue sites. A The PCA projections of the transcriptomic profiling of sorted PD-1⁺CD8⁺ T_RM cells for all samples, colored by different sample groups, and ellipses indicate differences between HBV⁺ and HBV⁻ samples. B The Venn plots of shared upregulated (left) and downregulated (right) differentially expressed genes of PD-1⁺CD8⁺ T_RM cells between HBV⁺ and HBV⁻ samples within INT and TB tissues. C The scatter plot of the log₂(fold change) of genes between HBV⁺ and HBV⁻ samples within INT and TB tissues, colored and labeled by shared upregulated and downregulated genes. D The GO pathway analyses of shared upregulated genes (left) and downregulated genes (right) between HBV⁺ and HBV⁻ samples as in (C), the pathway names were labeled. E and G The volcano plots of differentially expressed genes between HBV⁺ and HBV⁻ samples in INT tissues (E) and TB tissues (G), labeled with typical marker genes. F and H The GO pathway analyses of shared upregulated genes (left) and downregulated genes (right) between HBV⁺ and HBV⁻ samples in INT tissues (F) and TB tissues (H), the pathway names were labeled