Fig. 6

PAI-1 drives EndoMT and aberrant lymphangiogenesis and correlates with poor prognosis in CSCC. A Representative images of CSCC tissues stained for LYVE-1 (green), α-SMA (red), or PAI-1 (purple). Blue indicates the nucleus. B The correlation between PAI-1 expression level and LVD in CSCC tissues. C The correlation between PAI-1 expression level and the percentage of α-SMA.⁺LVs in CSCC tissues. D and E The OS (D) and DFS (E) of CSCC patients from the TCGA with lower versus higher PAI-1 expression were estimated using Kaplan–Meier curves. The median expression was used as the cut-off value. Data are presented as the mean ± SD. **P < 0.0001