Fig. 7From: Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cellsSchematic model. CAF-derived PAI-1 induces EndoMT in tumour-associated LECs by activating the LRP1/ERK1/2/AKT signalling pathway, which in turn drives abnormal lymphangiogenesis by increasing LEC migration, tube formation and monolayer permeability, thereby facilitating tumour lymphoinvasion and CSCC progressionBack to article page