Fig. 1
From: Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer
Ferroptosis inducers enhanced copper ionophores-induced cell death dependent on copper in liver cancer cells A and C. Cell viability of MHCC-97 H (A) or QBC939 (C) cells after Elesclomol (ES) 48 h treatment with DMSO, 10µM sorafenib (Sora) or 10µM Sora + 10µM TTM was measured with CCK-8 assay B and D. Cell viability of MHCC-97 H (B) or QBC939 (D) cells after Elesclomol (ES) 48 h treatment with DMSO, 10µM erastin (Era) or 10µM Era + 10µM TTM was measured with CCK-8 assay E and G. Cell viability of MHCC-97 H (E) or QBC939 (G) cells after diethyldithiocarbamate (DDC) 48 h treatment with DMSO, 10µM Sora or 10µM Sora + 10µM TTM was measured with CCK-8 assay F and H. Cell viability of MHCC-97 H (F) or QBC939 (H) cells after DDC 48 h treatment with DMSO, 10µM Era or 10µM Era + 10µM TTM was measured with CCK-8 assay. For A to G, media were supplemented with 1µM CuCl2