Fig. 6

CircZFR promotes tumor growth in vivo. a Survival was analyzed and compared between patients with high and low levels of circZFR. b Multivariable analysis of circZFR in LUAD TMA. c The expression of circZFR analyzed by CISH in TMA was correlated with T stage. Scale bar indicates 100 μm. d, e Representative data of xenograft tumors isolated from PDTX models (d) and tumors in nude mice-bearing HCC827 cells (e). f-h The inclusion levels of MYO1B exon23 (f), volumes (g) and weights (h) in xenograft tumors isolated from PDTX models. (n = 7 mice per group). i Multi-label IHC staining of H&E, HNRNPLL, phospho-AKT and phospho-mTOR. Scale bar indicates 100 μm. j-l The inclusion levels of MYO1B exon23 (j), volumes (k) and weights (l) of subcutaneous xenograft tumors isolated from nude mice (n = 7 mice per group). Data are shown as mean ± SD (n = 7). *p < 0.05, **p < 0.01, two-tailed Student’s t test