Fig. 1From: Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistanceTargeting HIF in conjunction with current therapies. Resistance to chemotherapy, radiotherapy and immunotherapy is associated with the activation of HIF and its downstream. To improve anti-tumor effect and diminish treatment resistance, HIF inhibitors together with cancer therapies would be a good solution for patients with resistant cancer. Abbreviations: HIF = hypoxia inducible factorBack to article page