Table 2 Synergistic effect via combination of radiation and HIF inhibitor

Colorectal cancer

HT29 and SW480

SN-38

Induces S and G2/M phases cell cycle arrest

PubChem CID: 104842

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/104842

[89]

Glioma

SU3

Vitexin:

HIF-1α inhibitor

Reduces glutathione, glutathione peroxidase and GLUT1, GLUT3

PubChem CID:

5280441

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/5280441

[90]

Breast cancer stem cell

MDA-MB-231 and MCF-7

Sorafenib

Induces G2/M cell cycle arrest

Inhibits metastasis

PubChem CID:

216239

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/216239

[91]

HNSCC

FaDu and ME180 xenograft model

HIF-1 knockdown

Increases oxygen consumption and killing of radiosensitive cell

[92]

SQ20B

Rapamycin

Inhibits the mTOR/HIF-1α axis

Elevation of HIF-2α

PubChem CID:

5284616

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/5284616

[93]

Non-small cell lung cancer

A549

Nelfinavir:

HIV protease inhibitor

Decreases HIF-1α/VEGF expression

PubChem CID:

64143

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/64143

[94]

A549

Endostar

Inhibits angiogenesis and tumor growth

PubChem CID:

187888

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/187888

[95]

H460 and HCC2429

GSI:

Notch pathway inhibitor

Inhibits Notch pathway and HIF-1

PubChem CID:

21741774

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/gamma-Secretase-Inhibitor-I

PubChem CID:

5712

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/Lificiguat

[96]

YC-1:

HIF-1 inhibitor

Triple-negative breast cancer

MDA-MB-231

Chrysin

Inhibits HIF-1α and enhancing radiation-induced apoptosis

PubChem CID:

5281607

URL:

https://pubchem.ncbi.nlm.nih.gov/compound/5281607

[97]