Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance

Table 4 Synergistic effect via combination of glycolysis inhibitor and HIF inhibitor

Drug	Agents associated with HIF-1	Mechanism	Cell line	Reference
3-BrPA 2-DG		Declines SOD1	MiaPaCa2 cell	[141] PubChem CID: 70684, 108223 URL: https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-bromopyruvate https://pubchem.ncbi.nlm.nih.gov/compound/108223
2-DG D-allose	SB202190	Enhances PARP cleavage Inhibits LDHA gene expression	MIA PaCa-2, BxPC-3, ASPC-1, and SK-OV-3 cells	[142] PubChem CID: 108223, 439507, 5169 URL: https://pubchem.ncbi.nlm.nih.gov/compound/439507 https://pubchem.ncbi.nlm.nih.gov/compound/5169
Dichloroacetate (DCA)	LY294002	Blocks the Akt/GSK‑3β/HIF‑1α signaling	Pulmonary arterial smooth muscle cells (PASMCs)	[145] PubChem CID: 25975, 3973 URL: https://pubchem.ncbi.nlm.nih.gov/compound/25975 https://pubchem.ncbi.nlm.nih.gov/compound/3973
2-DG	LY294002 PD(Polydatin)	Inhibits ROS/PI3K/AKT/HIF‐1α/HK2	MCF-7 and 4T1	[143] PubChem CID: 5281718 URL: https://pubchem.ncbi.nlm.nih.gov/compound/5281718
Cardamonin		Represses the mTOR/p70S6K pathway	MDA-MB-231 cells	[144] PubChem CID: 641785 URL:https://pubchem.ncbi.nlm.nih.gov/compound/641785

Abbreviation: SOD1 Superoxide dismutase 1, PARP Poly-ADP ribose polymerase, LDHA Lactate Dehydrogenase, ROS Reactive oxygen species, m-TOR Mechanistic target of rapamycin, PI3k Phosphoinositide-3-kinase, Akt Protein kinase B

ISSN: 1756-9966