Fig. 1
From: The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity
Scheme showing the regulation of HOTAIR expression. (A) The antisense transcription of the HOTAIR gene within the HOXC cluster genes can be controlled by a downstream distal enhancer (HOXC distal enhancer) and an intronic enhancer. The functionally characterized consensus sequences in the promoter region upstream the TSS are listed. (B) HOTAIR levels are post-transcriptionally controlled through the negative regulation by different miRNAs and through the HuR/Ago/let-7-mediated degradation