Fig. 3

Schemes showing the HOTAIR functions in post-transcriptional regulation of gene expression as a ceRNA in EMT. (A) Endogenous (or EV-delivered) HOTAIR sponges specific miRNAs that target pro-EMT transcripts, thus stabilizing them; (B) in the intercellular communication, HOTAIR ceRNA activity may control the abundance of anti-EMT miRNAs that are specifically sorted and loaded in exosomes, thus promoting EMT in receiving cells