Fig. 4

Schemes showing the HOTAIR functions in post-translational regulation of protein activity. (A) HOTAIR recruits a molecular platform including the E3 ligases Dzip3 and Mex3b. It can facilitate the assembly of Ataxin-1 with Dzip3, as well as of Runx2 with Mex3b, thus promoting ubiquitination and degradation of the transcription inhibitors and EMT-related gene expression (B) HOTAIR regulates MVB transport by controlling the expression and the localization of RAB-GTPase on MVB membrane. Moreover, the lncRNA promotes the docking between V-SNARE and T-SNARE allowing the fusion of MBV and plasma-membrane and the exosome secretion