Fig. 5

HOTAIR targeting approaches. (A) The mutant Hotair-sbid, lacking the domain recruiting EZH2, acts as a competitor of the endogenous HOTAIR for Snail binding, allowing the de-repression of epithelial genes. (B) The small compound AC1NOD4Q (ADQ) specifically binds the 5’ domain of HOTAIR interfering with the interaction between the lncRNA and EZH2 and with the expression of a pro-tumorigenic program of gene expression