Fig. 3From: Biological roles of A-to-I editing: implications in innate immunity, cell death, and cancer immunotherapyThe role of ADAR1 in regulating innate immune and cell death responses to dsRNA and Z-RNA: Upon ADAR1 depletion, unedited dsRNA triggers the pattern recognition receptor MDA5, PKR and unedited Z-RNA triggers ZBP1, both ultimately leading to interferon-induced and apoptotic antiviral mechanismsBack to article page