Fig. 5

DRD2 combined with β-catenin act as an indicator for poor prognosis in GBM patients with depression. A Hamilton scores were gradually upregulated as the advanced malignancy of gliomas. B High-depression GBM patients had a worse prognosis than the patients with low-depression. C&D Glioma lysates from patients with or without depression were subjected to immunoblotting (C) and quantified (D). Representative WB of three independent experiment is shown. E–H Representative images of immunohistochemical staining (E) and percentage (F–H) of DRD2 and β-catenin positive cells in glioma patients with or without depression. Scale bar: 100 μm. I-K Kaplan–Meier survival analysis of glioma patients with or without depression expressing indicated proteins. LGG: low grade glioma. HGG: high grade glioma. *P < 0.05, **P < 0.01, ***P < 0.001