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Table 3 Combination index (CI) of Pimozide and TMZ in U87 cells and U251 cells

From: Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop

Pimozide concentration

TMZ concentration

Effect of combination

CI value of combination*

Effect of combination

CI value of combinationa

  

U87

U251

U25

100 μM

0.28373

0.96996

0.29531

0.82261

5 μM

150 μM

0.47840

0.68454

0.45215

0.79553

5 μM

200 μM

0.73743

0.37861

0.64208

0.70405

10 μM

100 μM

0.64098

0.53620

0.46155

0.70405

10 μM

150 μM

0.80916

0.34826

0.72408

0.71122

10 μM

200 μM

0.87762

0.27606

0.87004

0.56626

  1. aCI < 1 indicated that there is a synergistic effect