Table 5 Clinical trials targeting the immune landscape for the treatment of metastatic colorectal cancer
Type of cancer vaccine | Tumour-associated antigen | Trial ID | Phase | Subject |
|---|---|---|---|---|
Cancer cell vaccine | Autologous cancer cells | NCT00016133 | Phase I/II | Stage II or III colon cancer |
Cancer cell vaccine | Autologous cancer cells | NCT02448173 | Phase III | Stage II colon cancer |
DC vaccine | Mutated peptides | NCT03730948 | Phase I | Stage I and II hypermutated colorectal cancer |
DC vaccine | Autologous tumour homogenate | NCT02919644 | Phase II | Stage IV colorectal cancer |
Peptide vaccine | GUCY2C–PADRE | NCT01972737 | Phase I | Stage I or stage II colon cancer |
Peptide vaccine | 12 unique epitopes | NCT03391232 | Phase I | mCRC |