Fig. 4
From: Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma
Adaptive CD8 T cells are required for therapeutic efficacy on controlater, untreated lesion. A. Graphs show mean volume for SD101-treated (upper panel) and untreated (lower panel) mOS69 tumors. Six animals per group were used. B. Graph shows the final tumor volumes from the experiment in panel A. Mann–Whitney test was used for statistical analysis. C. Multiparametric flow cytometry analysis of tumor infiltrating myeloid cells in both treated and untreated lesions from SD101- or PBS-treated mice. Data are expressed as percentage of specific cell subsets (shown on the Y axis). Data from single mice are shown (3 mice for BALB/c groups and 6 mice for nu/nu groups were analyzed). Mann–Whitney test was used for statistical analysis