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Fig.6 | Journal of Experimental & Clinical Cancer Research

Fig.6

From: Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC

Fig.6

PYGL promoted HNSCC malignancy by suppressing TP53 expression. A Prediction of cisplatin IC50 in high and low TP53 expression groups. B Pearson correlation analysis between PYGL and TP53 expression. C qRT-PCR of TP53 and P21 in PYGL knock-down groups (n = 3). D Western blot of p53 and p21 in PYGL knock-down groups. E Western blot of pygl and p53 in PYGL and TP53 knock-down groups. F Flow cytometry using DAPI and Ki67 for cell cycle phase ratio analysis in PYGL knock-down groups (n = 3). G Statistics of cell cycle phase ratios analyzed in Fig. 5F

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