Fig.8

EphA3 axis is involved in the evasion of RAGE-overexpressing BC cells and CAFs from Matrigel drops. A Representative phase contrast images from the Matrigel drops evasion assay from co-cultures of MCF7/wt or MCF7/RAGE cells and CAFs in the presence or absence of 10 μM EphA3 inhibitor AWL-II-38.3. B-C Percentage of cells around the drop upon 3 days treatment from three independent experiments performed in triplicate. Yellow arrows indicate CAFs. Purple arrows indicate MCF7/RAGE cells. The dotted line indicates the border of drop; scale bar: 650 μm. (*) indicates p < 0.05; (**) indicates p < 0.01