Fig. 2

Abnormal expression of ISG15 were associated with stemness and malignant cells. A The UMAP plot of 3 cell subsets. B The expression of cell markers in different cell subsets. C The UMAP plot of ISG15 positive and negative epithelial cell subsets. D The expression of ISG15 in different epithelial cell subsets. E The stemness scores in the epithelial cells. F The CNV scores calculated by the inferCNV in the epithelial cells. G The CNV scores of different cell classes grouped by the Kmeans. H The UMAP plot of CNV scores in the epithelial cells. I The trends of ISG15 expression, malignant cells and stemness along the trajectory of ATC progression