Fig. 1

The colon to liver metastases are more similar to the adjacent liver tissue than the primary tumors. a Principal component analysis of all the samples in the study. (CC = Colon Cancer, red; LM1/LM2/LM3 = Colon-to-liver metastasis first/second/third wave, blue; AL = adjacent liver, green). b. Principal component analysis of two publicly available datasets of RNAseq of primary colon cancer (CC, red), liver metastases (LM, blue), adjacent liver (AL, green) and normal colon (NC, brown) samples. c Total number of differentially expressed genes between the various conditions (notation as in a). A large number of genes is deregulated between CC and AL, while it decreases in metastatic samples when considering each wave separately or merging metastatic samples together (LM1 + LM2 + LM3). d-e Number of up- and down-regulated genes in metastatic samples compared to primary tumors. We reported separately the number of DE genes for matched CC and LM1 samples (see Table S1) and over all the samples (left) as well as those in common between the two. The tables in the bottom report, for each subset, the number of genes annotated as liver-enriched, intestine enriched or both intestine and liver enriched according to Protein Atlas (see also Tab. S2-S3)