Fig. 10

Pentoxifylline treatment partially reverted the 22-gene signature and downregulated most of the STAT3 putative target genes within the signature. Gene expression levels were assessed for the 22 genes comprising the identified colon to liver metastasis signature (Table 1) in pentoxifylline-treated PDO#1 and PDO#4 cultures (8 h, 20uM). Average of two independent experiments. Marked in purple are the genes deemed as or demonstrated to be STAT3 targets from literature data and promoter analysis