Fig. 5

Pentoxifylline exhibited synergistic activity with 5-FU toward the Organoid Forming Ability. Representative graphs of the effect of the combined pentoxifylline and 5-FU treatment on the organoid forming ability of PDO#1 (a) and PDO#4 (b). The Bliss synergy score calculated was > 32 and > 17 for PDO#1 and PDO#4, respectively, indicating synergistic effect of the two administered compounds. Details are available in the methods section