Fig. 2
From: Super-enhancers complexes zoom in transcription in cancer
Various potential factors for SE formation: Mutagenesis which leads to a new SE; Local amplification that mediates oncogenic SE activation; Chromosome translocation that mediates SE alteration; 3D structural alterations that result in the production of oncogenic SEs; Viral infection that mediates SE acquisition; Fusion genes induce the formation of SEs; Phase separation driven by SE; SE-mediated core regulatory circuitry. (SE = Super-enhancer)