Fig. 3

SE complexes, including the high density of TFs, HMEs, and SE-cofactors, such as BET family proteins, CDKs, and mediator complexes, are involved in the malignant phenotype of various tumors. This figure mainly proposed the correlation between SE complexes and tumor type. The green circles in the middle represent tumor types affected by SE complexes, other circles represent SE complexes, purple circles represent TF, blue represents HMEs, and yellow represents cofactors. For example, TF MYCN, ERG, HOXB13, USF1, TP63/SOX2, YY1 and CHD4 mediate SE, thereby affecting neuroblastoma, prostate cancer, hepatocellular carcinoma, squamous cell carcinoma, and rhabdomyosarcoma. HME NSD2, KDM6A, KDM5B, CBP/p300, P65, HDAC1, HDAC2, HDAC7 mediate SE, thereby affecting Multiple myeloma, rhabdomyosarcoma, breast cancer, hepatocellular carcinoma, glioblastoma. SE cofactors BRD2, BRDT, BRD4, CDK7, CDK9, MED1, MED12 mediate SE, thereby affecting Melanoma, squamous cell carcinomas, Multiple myeloma, neuroblastoma, chordoma, breast cancer, prostate cancer, giloma and colon cancer. ( GBM = Glioblastoma, HCC = Hepatocellular carcinoma, HMEs = Histone modifying enzymes, RMS = Rhabdomyosarcoma, SCC = Squamous cell carcinoma, TF = Transcription factor.)