Fig. 6

SE-associated miRNAs and SE-associated circRNAs mediated by TF and HMEs are implicated in the development of tumors. The circular outer ring represents the three SE complexes (Blue represents the TF, Pink stands for the HMEs, Green stands for the SE cofactors). The loop in the middle of the circle is the SE-associated miRNAs and SE-associated circRNAs regulated by the SE complex (Red word represents SE-associated miRNAs, Green word stands for the SE-associated circRNAs). The inner loop of the circle represents tumors affected by SE complexes that regulate SE-associated miRNAs and SE-associated circular RNAs. For instance, TF ASCL1 positively control SE-associated miRNAs (SE-miR-429, SE-miR-375, SE-miR-200b-3p, and SE-miR-7), which helps define molecular subtypes of small cell lung cancer. (CC = Colon cancer, CRC = Colorectal cancer, ETMRs = Embryonal tumors with multilayered rosettes, HCC = Hepatocellular carcinoma, HMEs = Histone modifying enzymes, LC = Lung cancer, SCLC = Small cell lung cancer, TF = Transcription factor.)